Publications Concerning Polymerx Technology

Rosario-Meléndez, R; Ouimet, MA; Uhrich “Optimized formulation of salicylate-based poly(anhydride-ester) microspheres for short- to long-term salicylic acid delivery” Journal of Microencapsulation, submitted.

Ouimet, MA; Snyder, S; Uhrich, KE “Tunable drug release profiles from salicylate-based poly(anhydride-ester) matrices using small molecule admixtures”, J Bioactive Compatible Polymers, submitted.

Yeagy, BA; Prudencio, A; Uhrich, KE; Cook, TJ “Factors that Influence Tg of Poly(anhydride-esters) Processed into Microspheres”, Biomaterials, submitted.


Reynolds, MA; Carbone, A; Aichelmann-Reidy, ME; Wharburton, G; Uhrich, KESalicylic Acid-based Polyanhydride Composite Bone Grafts”, J Biocompat Polym, submitted.

Reynolds, MA; Aichelmann-Reidy, ME; Wharburton, G; Uhrich, KE “Salicylic Acid-based Poly(anhydride esters) in Bone Regeneration”, Biomaterials, submitted.

Prudencio, A; Johnson, M; Song, MJ; Langowski, BA; Uhrich, KE “Synthesis and Characterization of a Novel Ampicillin-based Poly(anhydride-amide)”, J Bioact Compat Polym, in revision.

Carbone, AL; Uhrich, KE “Novel Polyanhydrides Exclusively Derived from Natural Antimicrobials and EDTA”, Macromol Rapid Comm, in revision.

Song, M; Carbone, A; Buettner, H; Uhrich, KE “Neuron growth and Schwann cell proliferation of NSAID-based poly(anhydride-esters)”, J Biomed Mater Res: Part A, in revision.

Anastasiou, T. and Uhrich, KE " Degradation and Erosion Behavior of Xylyl-based Polyanhydrides", J Appl Polym Sci, in revision.

Rosario-Melendez, R; Lavelle, L; Griffin, J; Bodnar, S; Halperin, F; Harper, I; Griffin, J; Uhrich, KE “Stability of salicylate-based poly(anhydride-ester) to electron beam and gamma radiation”, Polym Deg and Stability, 96, 1625-1630 (2011).

Griffin, J; Delgado-Rivera, R; Meiners, S; Uhrich, KE “Salicylic acid-derived poly(anhydride-ester) electrospun fibers designed for regenerating the peripheral nervous system”, J Biomed Mater Res: Part A, 97 (3) 230-242 (2011).

Delgado-Rivera, R; Griffin, J; Ricupero, C; Grumet, M; Meiners, S; Uhrich, KE “Microscale Plasma-initiated Patterning of Electrospun Polymer Scaffolds Coll Surf B: Biointerfaces, 84, 591-596 (2011).

Kim, Y and Uhrich, KE “Synthesis and characterization of 5-aminosaliyclic acid-based poly(anhydride-esters) by solution polymerization”, J Polym Sci: Part A, 48 (24) 6003-6008 (2010).

deRonde, BM; Carbone, AL; Uhrich, KEStorage Stability Study of Salicylate-based Poly(anhydride-esters)", Polymer Degradation and Stability, 95, 1778-1782 (2010).

Griffin, J; Carbone, A; Delgado-Rivera, R; Meiners, S; Uhrich, KE “Design and Evaluation of Novel Polyanhydride Blends as Nerve Guidance Conduits Acta Biomateriala, 6, 1917-1924 (2010).

Mazumdar, N; Tchikindas, M; Uhrich, KE “Slow Release Polymer-iodine Tablets for Disinfection of Untreated Surface Water”, J Appl Polym Sci, 117 (1) 329-334 (2010).

Prudencio, A; Carbone, AL; Griffin J; Uhrich, KEA Novel Approach for Incorporation of Mono-functional Bioactive Phenols into Polyanhydrides”, Macromol Rapid Comm, 30, 1101-1108 (2009).

Carbone, AL; Uhrich, KE “ “Design and Synthesis of Fast-Degrading Poly(anhydride-esters)”, Macromol Rapid Comm, 30 (12) 1021-1026 (2009).

Johnson, M and Uhrich, KE “Concurrent Release of Admixed Antimicrobials and Salicylic Acid from Salicylate-based Poly(anhydride-esters)”, J Biomed Mater Res, 91A (3) 671-678 (2009).

Carbone, AL, Song, MJ and Uhrich, KE “Iodinated salicylate-based poly(anhydride-esters) as radiopaque biomaterials”, Biomacromolecules, 9 (6)

1604–1612 (2008).


Schmeltzer, R; Johnson, J; Griffin, J; and Uhrich, KE "Comparison of salicylate-based poly(anhydride-esters) formed via melt condensation vs. solution polymerization”, J. Biomater. Sci. Polymer Ed., 19 (10) 1295-1306 (2008). [invited]

Reynolds, MA; Prudencio, A; Aichelmann-Reidy, ME, Woodward, K; and Uhrich, KE “Non-steroidal Anti-inflammatory Drug (NSAID)-derived Poly(anhydride-esters) in Bone and Periodontal Regeneration”, Curr. Drug Delivery, 4 (3) 233-239 (2007).

Yeagy, B; Prudencio, A; Schmeltzer, RC; Uhrich, KE and Cook, TJ “Characterization and In Vitro Degradation of Microspheres Based on Novel Salicylate Poly(anhydride-esters)”, J. Microencapsulation, 23 (6) 643-653 (2006).

Schmeltzer, R; and Uhrich, KE "Synthesis and characterization of antiseptic-based poly(anhydride-esters)”, Polym. Bull., 57 (3) 281-291 (2006).

Bryers, JD; Jarvis, RA; Lebo, J; Prudencio, A; Kyriakides, TR and Uhrich, K “Biodegradation of Poly(anhydride-esters) into Non-steroidal Anti-inflammatory Drugs and Their Effect on Pseudomonas aeruginosa Biofilms in vitro and on the Foreign Body Response in vivo”, Biomaterials, 27 (29) 5039-5048 (2006).

Schmeltzer, R; and Uhrich, KE "Synthesis and Characterization of Salicylic Acid-based Poly(anhydride-ester) Copolymers” , J. Bioactive Compat. Polym., 21 (2) 123-133 (2006).

Whitaker-Brothers, K and Uhrich, K “Investigation into the Erosion Mechanism of Salicylate-based Poly(anhydride-esters)”, J. Biomed. Mater. Res.: Part A, 76A, 470-479 (2006).

Prudencio, A; Schmeltzer, RC and Uhrich, KE "Effect of Linker Structure on Salicylic Acid-derived Poly(anhydride-esters)", Macromolecules, 38, 6895-6901 (2005).

Harten, RD; Svach, DJ; Schmeltzer, R; and Uhrich, KE "Salicylic Acid-derived Poly(anhydride-esters) Inhibit Bone Formation In Vivo", J. Biomed. Mater. Res.: Part A, 72A (4) 354-362 (2005) 

Schmeltzer, R; Schmalenberg, K; and Uhrich, KE " Synthesis and Cytotoxicity of Salicylate-based Poly(anhydride-esters)", Biomacromolecules, 6 (1) 359-367 (2005).

Whitaker-Brothers, K and Uhrich, KE "Poly(anhydride-esters) Fibers: Role of Copolymer Composition on Hydrolytic Degradation and Mechanical Properties", J. Biomed. Mater. Res., 70A (2) 309-318 (2004).

Schmeltzer, RC; Anastasiou, TJ and Uhrich, KE "Optimized Synthesis of Salicylate-based Poly(anhydride-esters)", Polym. Bull. 49 (6) 441-448 (2003).

Anastasiou, T. and Uhrich, KE "Aminosalicylate-based Biodegradable Polymers: Synthesis and In Vitro Characterization of Poly(anhydride-esters) and Poly(anhydride-amides)", J. Polym. Sci. A: Polym. Chem., 41, 3667-3679 (2003). [invited].

Deng, M.; Uhrich, KE and Shalaby, SW "Effects of In Vitro Degradation on Properties of Poly(DL-lactide-co-glycolide) Pertinent to Its Biological Performance", J. Mater. Sci-Mater. M. 13 (11) 1091-1096 (2002).

Bedell, C.; Deng, M.; Anastasiou, T. and Uhrich, KE "Processing and Hydrolytic Degradation of Aromatic, Ortho-substituted Polyanhydrides", J. Appl. Polym. Sci., 80, 32-38 (2001).

Anastasiou, T. and Uhrich, KE "Novel Polyanhydrides with Enhanced Thermal and Solubility Properties", Macromolecules, 33 (17) 6217-6221 (2000).

Erdmann, L. and Uhrich, KE "Synthesis and Degradation Characteristics of Salicylic Acid-derived Poly(anhydride-esters)”, Biomaterials, 21 (19) 1941-1946 (2000).

Erdmann, L.; Macedo, B. and Uhrich, KE "Degradable Poly(anhydride-ester) Implants: Effects of Localized Salicylic Acid Release on Bone", Biomaterials, 21 (24) 2507-2512 (2000). [invited]

Attawia, MA; Herbert, KM; Uhrich, KE; Langer, R. and Laurencin, CT "Proliferation, Morphology, and Protein Expression by Osteoblasts Cultured on Poly(anhydride-co-imides)", J. Biomed. Mater. Res. (Appl. Biomater.), 48, 322-327 (1999).

Campo, CJ; Anastasiou, T. and Uhrich, KE "Polyanhydrides: Effects of Ring Substitution Changes on Polymer Properties", Polym. Bull., 42 (1) 61-68 (1999).

Uhrich, KE; Cannizzaro, SM; Langer, RS and Shakesheff, K. "Polymeric Systems for Controlled Drug Release", Chem. Rev., 99 (11) 3181-3198 (1999). [invited].

Jiang, A. and Uhrich, KE "Polymer-Salt Complexes as Solid Electrolytes", Polym. News, 24, 221-225 (1999). [invited]

Ibim, SEM; Uhrich, KE; Attawia, M.; Shastri, VK; El-Amin, SF; Bronson, R.; Langer, R. and Laurencin, CT "Preliminary In Vivo Report on the Osteocompatibility of Poly(anhydride-co-imides) Evaluated in a Tibial Model", J. Biomed. Mater. Res. (Appl. Biomater.), 43 (4), 374-379 (1998).

Uhrich, KE; Ibim, SEM; Larrier, D.; Langer, R. and Laurencin, CT "Chemical Changes During In Vivo Degradation of Poly(anhydride-imide) Matrices", Biomaterials, 19 (22) 2045-2050 (1998).

Ibim, SM; Uhrich, KE; Bronson, R.; El-Amin, SF; Langer, RS and Laurencin, CT "Poly(anhydride-co-imides): In Vivo Biocompatibility in a Rat Model", Biomaterials, 19 (10) 941-951 (1998).

Deng, M and Uhrich, KE "Analysis of Thermal Transitions of Polymeric Biomaterials. Part I: Ultrahigh Molecular Weight Polyethylene", J. App. Polym. Sci., 68 (8) 1353-1361 (1998). 

Uhrich, KE; Thomas, TT; Laurencin, CT and Langer, R. "In Vitro Degradation of Poly(anhydride-imides) Containing Trimellitylimidoglycine", J. Appl. Polym. Sci., 63 (11) 1401-1412 (1997).

Attawia, MA; Uhrich, KE; Botchwey, E.; Langer, R. and Laurencin, CT "In Vitro Bone Biocompatibility of Poly(anhydride-co-imides) Containing Pyromellitylimidoalanine", J. Ortho. Res., 14 (3) 445-454 (1996).

Seidel, JO; Uhrich, KE; Laurencin, CT and Langer, R. "Erosion of Poly(anhydride-co-imides): A preliminary mechanistic study", J. Appl. Polym. Sci., 62 (8) 1277-1283 (1996).

Uhrich, KE; Larrier, DR; Laurencin, CT and Langer, R. "In Vitro Degradation Characteristics of Poly(anhydride-imides) Containing Pyromellitylimidoalanine", J. Polym. Sci., Part A: Polym. Chem., 34 (7) 1261-1269 (1996).

Attawia, MA; Uhrich, KE; Botchwey, E.; Fan, M.; Langer, R. and Laurencin, C. "Cytotoxicity Testing of Poly(anhydride-co-imides) for Orthopedic Applications", J. Biomed. Mater. Sci., 29 (10) 1233-1240 (1995).

Uhrich, KE; Gupta, A.; Thomas, TT; Laurencin, CT and Langer, R. "Synthesis and Characterization of Degradable Poly(anhydride-co-imides) for Orthopedic Devices", Macromolecules, 28 (7) 2184-2193 (1995).